The CADET-UD Trial is investigating whether candesartan (compared to a placebo) helps to reduce symptoms of major depression and improve quality of life. Major depressive disorder may, in part, be caused by inflammation and oxidative stress in the brain. Candesartan, a commonly used blood pressure medication, may help to reduce the inflammation and oxidative stress and restore some neuronal function. Candesartan may be beneficial in reducing symptoms of major depression.

The CADET-UD Trial has clinics in Melbourne, Geelong, Sydney and Brisbane and is looking for participants 18 years or older with a diagnosis of major depressive disorder to take part. Whilst on the study our participants trial candesartan medication or placebo, in addition to their usual treatments, for 16 weeks and meet with a researcher for up to 7 visits at one of our clinics. There is no cost to take part in the trial, and once enrolled our participants receive a small re-imbursement for travel expenses.

If you or someone you know;

  • Has been diagnosed with major depressive disorder,
  • Is currently experiencing a low mood,
  • Is 18 years or older,
  • And would be interested in participating in this clinical trial,

Please contact the CADET-UD team to receive more information about the study or enquire about participating.

Contact details

Trial locations

Barwon Health

285 Ryrie St, Geelong

The Melbourne Clinic

130 Church St, Richmond
VIC 3121

Albert Road Clinic

31 Albert Road
VIC 3004

Toowong Specialist Clinic

54 Jephson St
QLD 4066

Eastern Health

5 Arnold St
Box Hill
VIC 3128

Register your interest to participate in our research studies.

If you are interested in taking part in our research studies you can sign up to the database and we will keep you informed about current or future opportunities.